Cytotoxic and antiviral potentials of Euphorbia milii var. splendens leaf against Peste des petits ruminant virus
نویسندگان
چکیده
Purpose: To determine the cytotoxic and antiviral potentials of Euphorbia milii var. splendens leaf against Peste des petits ruminants virus (PPRV).
 Methods: The methanol extract, as well n- hexane, chloroform, ethyl acetate, butanol fractions E. leaves were screened for activities PPRV using Vero cell line 3-(4,5-dimethylthiazol-2-yl)-2,diphenyltetrazolium bromide (MTT) assay.
 Results: Non-cytotoxic concentrations with survival rate (CSP) greater than 50 % considered virucidal. Methanol extract produced significant (p < 0.05) effects at all test PPRV. concentration (CC50) calculated was ≤ 25 µg/mL fractions. In assay, n-hexane, n-butanol ranging from 1.56 - 800 non-virucidal; even their non-cytotoxic these did not show activities. However, its chloroform showed virucidal potential.
 Conclusion: results suggest that further isolation constituents may open new horizons development agents.
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ژورنال
عنوان ژورنال: Tropical Journal of Pharmaceutical Research
سال: 2021
ISSN: ['1596-5996', '1596-9827']
DOI: https://doi.org/10.4314/tjpr.v18i7.21